Lifahleho tse tharo tsa bo-'m'e tsa Baegepeta ba khale li senotsoe ka mokhoa o makatsang

Baegepeta ba boholo-holo ba ne ba shebahala joang lilemong tse 2,000  tse fetileng? Na ba ne ba e-na le letlalo le lefifi le moriri o harelaneng? Laeborari e thehiloeng Virginia e atlehile ho bopa lifahleho tsa li-mummies tse tharo e sebelisa DNA ea bona.

Liphiri tsa Egepeta ea boholo-holo li ntse li tsoela pele ho khahla batho lefatšeng ka bophara. Liphiramide tse ikhethang, li-hieroglyphs tse rarahaneng, le meetlo e rarahaneng ea lepato e hapile mehopolo ea bo-rasaense le bo-rahistori ka lilemo tse ngata.

Sphinx le Piramids, Egepeta
The Sphinx le Piramids, e tummeng Wonder of the World, Giza, Egepeta. © Anton Aleksenko/Nako ea litoro

Hona joale, ka thuso ea theknoloji e tsoetseng pele, re ka khona ho bona hore na batho ba mehleng eo ba ne ba shebahala joang. Ka Loetse 2021, bo-ramahlale ba ile ba senola lifahleho tse nchafalitsoeng tsa banna ba bararo ba neng ba lula Egepeta ea khale lilemong tse 2,000 tse fetileng ka theknoloji ea dijithale, ho re lumella ho li bona kamoo li neng li tla shebahala kateng ha ba le lilemo li 25.

Ts'ebetso ena e qaqileng, e neng e itšetlehile ka data ea DNA e nkiloeng ho bona mesaletsa e senyehileng, e file bafuputsi fensetere e ncha ea bophelo ba Baegepeta ba boholo-holo.

Lifahleho tse tharo tsa 'm'e tsa khale tsa Egepeta li senotsoe ka kaho e makatsang 1
Kaho e ncha ea forensic ea li-mummies JK2911, JK2134 le JK2888. © Parabon NanoLabs

Litopo li ne li tsoa Abusir el-Meleq, e leng motse oa boholo-holo oa Egepeta o pel’a thota ea likhohola ka boroa ho Cairo, ’me li ile tsa patoa pakeng tsa 1380 BC le AD 425. Bo-rasaense ba Max Planck Institute for the Science of Human History e Tübingen, Jeremane, tatellano ea DNA ea li-mummies ka 2017; e ne e le lekhetlo la pele le atlehileng la ho tsosolosa liphatsa tsa lefutso tsa 'mè oa Egepeta oa boholo-holo.

Bafuputsi ho Parabon NanoLabs, e leng DNA khamphani ea thekenoloji e Reston, Virginia, e sebelisitse boitsebiso ba liphatsa tsa lefutso ho theha mefuta ea 3D ea lifahleho tsa li-mummies ho sebelisa forensic DNA phenotyping, e sebelisang tlhahlobo ea liphatsa tsa lefutso ho bolela esale pele sebōpeho sa sefahleho le likarolo tse ling tsa ponahalo ea 'mele ea motho.

"Lena ke lekhetlo la pele DNA phenotyping e felletseng e etsoa ho DNA ea motho ea lilemo tsena," baemeli ba Parabon ba boletse polelong. Parabon o ile a senola lifahleho tsa bo-'mè ka la 15 Loetse, 2021, Kopanong ea Bo-32 ea Machaba ea Boitsebiso ba Batho e Orlando, Florida.

Snapshot, e leng sesebelisoa sa phenotyping se entsoeng ke bo-rasaense, se ile sa sebelisoa ho fumana leloko la motho, 'mala oa letlalo le litšobotsi tsa sefahleho. Ho latela polelo, banna ba ne ba e-na le letlalo le sootho le nang le mahlo a lefifi le moriri; sebōpeho sa bona sa liphatsa tsa lefutso se ne se le haufi le sa batho ba kajeno ba Mediterranean kapa Bochabela bo Hare ho feta ba Baegepeta ba kajeno.

Bafuputsi ba ile ba theha li-meshes tsa 3D tse hlalosang likarolo tsa sefahleho sa 'mè, hammoho le limmapa tsa mocheso tse totobatsang phapang pakeng tsa batho ba bararo le ho ntlafatsa lintlha tsa sefahleho ka seng. Liphetho li ile tsa kopanngoa ke sebini sa Parabon ea forensic le likhakanyo tsa Snapshot mabapi le letlalo, mahlo le 'mala oa moriri.

Ho ea ka Ellen Greytak, mookameli oa Parabon oa bioinformatics, ea sebetsang le DNA ea motho ea boholo-holo e ka ba phephetso ka mabaka a mabeli: DNA hangata e senyeha haholo, 'me hangata e kopantsoe le DNA ea baktheria. "Pakeng tsa lintlha tseo tse peli, palo ea DNA ea motho e fumanehang ka tatellano e ka ba nyane haholo," ha rialo Greytak.

Lifahleho tse tharo tsa 'm'e tsa khale tsa Egepeta li senotsoe ka kaho e makatsang 2
© Univesithi ea California San Francisco

Bo-rasaense ha ba hloke genome e feletseng ho fumana setšoantšo sa 'mele oa motho hobane boholo ba DNA bo arolelanoa ke batho bohle. Ho e-na le hoo, ba hloka feela ho hlahloba libaka tse itseng tsa genome tse fapaneng pakeng tsa batho, tse tsejoang e le li-nucleotide polymorphisms tse le 'ngoe (SNPs). Ho ea ka Greytak, tse ngata tsa li-SNPs li na le khoutu ea ho se tšoane ha 'mele pakeng tsa batho ka bomong.

Lifahleho tse tharo tsa 'm'e tsa khale tsa Egepeta li senotsoe ka kaho e makatsang 3
Limmapa tse futhumatsang tsa lifahleho tse fapaneng li ile tsa nolofalletsa bo-rasaense ho ntlafatsa lintlha le ho totobatsa phapang pakeng tsa litšobotsi tsa litopo. © Parabon NanoLabs

Leha ho le joalo, ho na le maemo ha DNA ea boholo-holo e se na SNP e lekaneng ho supa tšobotsi e itseng. Maemong a joalo, bo-rasaense ba ka fumana boitsebiso bo sieo ba liphatsa tsa lefutso ho tsoa ho litekanyetso tsa SNP tse potolohileng, ho ea ka Janet Cady, rasaense oa Parabon bioinformatics.

Lipalopalo tse baloang ho likete tsa liphatsa tsa lefutso li bonts'a hore na SNP ka 'ngoe e amana hakae le moahelani ea sieo, Cady o hlalositse. Joale bafuputsi ba ka etsa khakanyo ea lipalo-palo mabapi le hore na SNP e sieo e ne e le eng. Mekhoa e neng e sebelisoa litopong tsena tsa boholo-holo e ka boela ea thusa bo-rasaense ho tsosolosa lifahleho ho bona litopo tsa mehleng ena.

Ho fihlela joale, linyeoe tse robong ho tse ka bang 175 tseo bafuputsi ba Parabon ba thusitseng ho li rarolla ka ho sebelisa leloko la lefutso li ithutile ho sebelisa mekhoa e tsoang thutong ena.

Ruri hoa hlolla ho bona batho bana ba tsosoa bafung lilemo tse 2,000  hamorao ka tšebeliso ea boitsebiso ba DNA le theknoloji ea morao-rao.

Lintlha tse qaqileng le ho nepahala ha likaha bocha lia hlolla, 'me re thabile ho bona kamoo tsoelopele ea nakong e tlang ea theknoloji e ka re thusang ho utloisisa hamolemo. baholo-holo ba rōna ba boholo-holo. 


Boitsebiso bo eketsehileng: Parabon® e Nchafatsa Lifahleho tsa 'M'e oa Baegepeta ho tsoa ho DNA ea Khale